Cefuroxime + Sulbactam is a combination of two medicines: Cefuroxime and Sulbactam. Cefuroxime is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Sulbactam is a beta-lactamase inhibitor which blocks the action of enzymes produced by bacteria to inactivate Cefuroxime. Addition of Sulbactam reduces resistance and enhances the activity of Cefuroxime against bacteria.